East Vs. West: A Systematic Review of Gut Microbiota Composition in Severe and Pervasive Psychological Disorders Under Asian and Western and Diets

Date of Award

5-2022

Document Type

Thesis

Degree Name

Master of Science in Biology

First Advisor

Dr. rer. nat. Crisanto M. Lopez

Abstract

This systematic review used the gut microbiota hypothesis as a critical lens to understand the associations between and among diet, gut microbial profiles, and the severity of symptoms of depression and anxiety. Studies yielded from the literature search were analyzed using synthesis without meta-analysis. More specifically, a narrative synthesis was performed using thematic analysis as the main tool to synthesize data. Four main themes were identified following thematic analysis: (1) depression and anxiety tell a story about inflammation, (2) an abundance of beneficial microorganisms is related to less severe depression and anxiety, (3) symptoms of depression and anxiety can be improved and managed through the adherence to the healthy Asian diet, and (4) the gut microbiota mediates the relationship between diet and depression and anxiety. The outcome of the review provides a basis for using adherence to Asian diet or its components to manage the symptoms of depression and anxiety.

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