Novel glycerol crosslinked poly(methyl methacrylate) synthesized by chemo-enzymatic method for controlled release application

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The most common methods of administering drugs are oral and intravenous, which have major limitations such as low specificity, toxicity, and high degradability. While studies on drug-carrier nanoparticles of poly-ε-caprolactone (PCL) were conducted, this study sought to modify the poly-ε-caprolactone polymer using glycerol as drug-carrier that can encapsulate and release less hydrophobic drugs. In this study, poly-ε-caprolactone was synthesized as well as crosslinked with glycerol simultaneously using Novozym 435 as the biocatalyst. This glycerol modified poly-ε-caprolactone was further converted into nanoparticles of size 100-400 nm by nanoprecipitation technique. The potential of glycerol modified poly-ε-caprolactone (GMPCL) to encapsulate and release propafenone was studied and the results were compared with that obtained from poly-ε-caprolactone nanoparticles. Findings reveal that these nanoparticles are most stable in pH 7 buffer as compared to pH 4 and pH 10 buffers. 10% (v/v) glycerol modified PCL could encapsulate 62 µg of drug in 30 minutes, whereas PCL without glycerol encapsulated 24 µg of drug in same time interval. Propafenone got released at a controlled rate at pH 7.4 and 37.4 °C from all the formulations. Maximum release was observed in the case of 10% (v/v) glycerol modified nanoparticles where 31% of encapsulated drug got released in 30 minutes whereas 29 % got released from PCL counterpart in the same time interval.