Title

Novel glycerol crosslinked poly(methyl methacrylate) synthesized by chemo-enzymatic method for controlled release application

Document Type

Article

Publication Date

2014

Abstract

The most common methods of administering drugs are oral and intravenous, which have major limitations such as low specificity, toxicity, and high degradability. While studies on drug-carrier nanoparticles of poly-ε-caprolactone (PCL) were conducted, this study sought to modify the poly-ε-caprolactone polymer using glycerol as drug-carrier that can encapsulate and release less hydrophobic drugs. In this study, poly-ε-caprolactone was synthesized as well as crosslinked with glycerol simultaneously using Novozym 435 as the biocatalyst. This glycerol modified poly-ε-caprolactone was further converted into nanoparticles of size 100-400 nm by nanoprecipitation technique. The potential of glycerol modified poly-ε-caprolactone (GMPCL) to encapsulate and release propafenone was studied and the results were compared with that obtained from poly-ε-caprolactone nanoparticles. Findings reveal that these nanoparticles are most stable in pH 7 buffer as compared to pH 4 and pH 10 buffers. 10% (v/v) glycerol modified PCL could encapsulate 62 µg of drug in 30 minutes, whereas PCL without glycerol encapsulated 24 µg of drug in same time interval. Propafenone got released at a controlled rate at pH 7.4 and 37.4 °C from all the formulations. Maximum release was observed in the case of 10% (v/v) glycerol modified nanoparticles where 31% of encapsulated drug got released in 30 minutes whereas 29 % got released from PCL counterpart in the same time interval.

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