Structure of a mutagen from roasted seeds of Moringa oleifera
A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(α-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(α-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound.
Irene M. Villasenor, Paul Finch, Clara Y. Lim-Sylianco, Fabian Dayrit, Structure of a mutagen from roasted seeds of Moringa oleifera, Carcinogenesis, Volume 10, Issue 6, June 1989, Pages 1085–1087, https://doi.org/10.1093/carcin/10.6.1085